Pere Ginès, Maja Thiele, Isabel Graupera, Miquel Serra-Burriel, Robert J de Knegt, Frank Lammert, Laurent Castera, Marko Korenjak, Patrick S Kamath, Ivica Grgurević, Salvatore Piano, Núria Fabrellas, Anita Arslanow, Aleksander Krag. Screening for fibrosis to diagnose liver diseases early: the LIVERSCREEN project. Nat Med, 2023 29, 774-775. DOI: 10.1038/s41591-023-02265-z.
Thiele M, Johansen S, Israelsen M, Trebicka J, Abraldes JG, Gines P, Krag A; MicrobPredict, LiverScreen, LiverHope and GALAXY consortia. Noninvasive assessment of hepatic decompensation. Hepatology. 2025 Mar 1;81(3):1019-1037. DOI: 10.1097/HEP.0000000000000618.
Pere Ginès, Indra Neil Guha, Núria Fabrellas, Alina M. Allen, Paolo Angeli, Miquel Serra-Burriel, Anita Arslanow, Willem Pieter Brouwer, Llorenç Caballeria, Marta Carol, Laurent Castera, Marta Cervera, Rob de Knegt, Harry J. de Koning, Sonke Detlefsen, Alba Díaz, Núria Fabrellas, Josep Lluis Falcó, Matilde Fuentes, Zaira García, Pere Ginès, Jordi Gratacós-Ginès, Isabel Graupera, Ivica Grgurevic, Indra Neil Guha, Eva Guix, Rosario Hernández-Ibañez, Jordi Hoyo, Luis Ibáñez-Samaniego, Adrià Juanola, Marko Korenjak, Aleksander Krag, Frank Lammert, Ann T. Ma, Anita Madir, Rosa M. Morillas, Ruth Nadal, J.M. Navarrete, Martina Pérez, Salvatore Piano, Judit Pich, Elisa Pose, Dominique Roulot, Jörn Schattenberg, Miquel Serra-Burriel, Lubomir Skladany, Anna Soria, Patricia Such, Maja Thiele, Marta Tonon, Pere Toran, Antoni Torrejón, Emmanuel A. Tsochatzis. Liver Health: An Emerging Concept. Gastroenterology. 2025 Jul;169(1):4-8.e1. doi: 10.1053/j.gastro.2024.12.039. Epub 2025 Feb 3.
Elisa Pose, Salvatore Piano, Maja Thiele, Núria Fabrellas, Emmanuel A Tsochatzis , Pere Ginès . Moving diagnosis of liver fibrosis into the community. J Hepatology 2025 Jul;83(1):258-270. doi: 10.1016/j.jhep.2025.01.026. Epub 2025 Jan 30.
Maja Thiele, Elisa Pose, Adrià Juanola, Jessica Mellinger, Pere Ginès. Population screening for cirrhosis. Hepatol Commun 2024 Aug 26;8(9):e0512. doi: 10.1097/HC9.0000000000000512
Isabel Graupera, Maja Thiele, Laurent Castera, Guillem Pera, Salvatore Piano, Sòria, Núria Fabrellas, Pere Toran, CarlA Chacon, Katrine T Bech, Helle Lindholm Schnefeld, Marta Tonon, Simone Incicco, Joël Moussy, Vincent Lévy, Anita Madir, Sandro Kukic, Daniel Jan Havaj, Svetlana Adamcova-Selcanova, Jesse Pustjens, Laurens A van Kleef, MD, Alba Jiménez-Masip, Laura Pagès, Mirko Zoncapè, Susanne N Weber, Peter R Galle, Rebecca Harris, Luis Ibáñez-Samaniego, Rosa M Morillas, Alba Diaz, Sönke Detlefsen, Miquel Serra-Burriel, Anita Arslanow, Peter Andersen,Judit Pich, Eva Bonfill, Marko Korenjak, Céline Fournier-Poizat, Anne Llorca, Marie-Caroline Gourmelon, Prof. Harry J de Koning, Martina Pérez-Guasch, Ann Thu Ma, Adrià Juanola, Elisa Pose, Ingrid Arteaga, Ida Villesen, Johanne Kragh Hansen, Valeria Calvino, Roberta Gagliardi, Bahija Boutouria, Frane Pastrovic, Petra Dinjar Kujundzic, Daniela Zilincanova, Karolina Kristina Sulejova, Diego Rojo, Robert J de Knegt, Maykon Diego Melo, Antonio Torrejón, Rosario Hernández-Ibáñez, Jordi Hoyo,Laura Muñoz, Raquel López-Martos, Simon J Griffin, Michael Manns, Tom H Karlsen, Phil N Newsome, Patrick S Kamath, Rafael Bañares, Indra N Guha, Jörn M Schattenberg, Prof. Frank Lammert, Emmanuel Tsochatzis, Willem P Brouwer, Juan M Pericàs, Lubomir Skladany, Ivica Grgurevic, Dominique Roulot, Paolo Angeli, Aleksander Krag, Llorenç Caballeria, Pere Ginès. Prevalence of liver fibrosis in the general population: a multinational European cohort study. The LiverScreen project’. The Lancet (accepted, February 2026).
Pere Ginès, Aleksander Krag, Juan G Abraldes, Elsa Solà, Núria Fabrellas, Patrick S Kamath.
Liver cirrhosis.
The Lancet, Seminar 2021 Oct 9: p1359-1376. DOI: link. Since the paper is an invited seminar, it is not eligible for open access, yet it is highly important for the project
Isabel Graupera, Maja Thiele, Ann T Ma, Miquel Serra-Burriel, Judit Pich, Núria Fabrellas, Llorenç Caballeria, Robert J de Knegt, Ivica Grgurevic, Mathias Reichert, Dominique Roulot, Jörn M Schattenberg, Juan M Pericas, Paolo Angeli, Emmanuel A Tsochatzis, Indra Neil Guha, Montserrat Garcia-Retortillo, Rosa M Morillas, Rosario Hernández, Jordi Hoyo, Matilde Fuentes, Anita Madir, Adrià Juanola, Anna Soria, Marta Juan, Marta Carol, Alba Diaz, Sönke Detlefsen, Pere Toran, Céline Fournier, Anne Llorca, Phillip N Newsome, Michael Manns, Harry J de Koning, Feliu Serra-Burriel, Fernando Cucchietti, Anita Arslanow, Marko Korenjak, Laurens van Kleef, Josep Lluis Falcó, Patrick S Kamath, Tom H Karlsen, Laurent Castera, Frank Lammert, Aleksander Krag , Pere Ginès, LiverScreen Consortium investigators.
LiverScreen project: study protocol for screening for liver fibrosis in the general population in European countries
BMC Public Health, 2022 Jul 19;22(1):1385. doi: 10.1186/s12889-022-13724-6.
Pere Ginès, Laurent Castera, Frank Lammert, Isabel Graupera, Miquel Serra-Burriel, Alina M. Allen, Vincent Wai-Sun Wong, Phillipp Hartmann, Maja Thiele, Llorenç Caballeria, Ivica Grgurevic, Salvador Augustin, Emmanuel. A Tsochatzis, Jörn M. Schattenberg, Indra Neil Guha, Andrea Martini, Rosa M Morillas, Montserrat Garcia-Retortillo, Harry J de Koning, Núria Fabrellas, Judit Pich, Ann T Ma, Mª Alba Diaz, Dominique Roulot, Philip N Newsome, Michael Manns, Patrick S. Kamath, Aleksander Krag.
Population screening for liver fibrosis. Towards early diagnosis and intervention for chronic liver diseases
Hepatology, 2022 Jan;75(1):219-228. DOI: 10.1002/hep.32163.
Rachel Pryke, I. Neil Guha.
Time to focus chronic liver diseases back into the community: A review of primary care hepatology tools, pathways of care and reimbursement mechanisms.
Journal of Hepatology, 2022 Oct 22:S0168-8278(22)03146-4. Review article. DOI: https://doi.org/10.1016/j.jhep.2022.10.010.
Charlotte W. Wernberg, Kim Ravnskjaer, Mette M. Lauridsen and Maja Thiele.
The Role of Diagnostic Biomarkers, Omics Strategies, and Single-Cell Sequencing for Nonalcoholic Fatty Liver Disease in Severely Obese Patients
J. Clin. Med. 2021, 10(5), 930. doi: https://doi.org/10.3390/jcm10050930
Miquel Serra-Burriel, Isabel Graupera , Maja Thiele , Llorenç Caballeria, Dominique Roulot, Grace Lai-Hung Wong, Núria Fabrellas , Neil Guha, Anita Arslanow Carmen Expósito , Rosario Hernández, Guruprasad Aithal , Peter Galle, Vincent Wai-Sun Wong, Frank Lammert, Castera Laurent, Aleksander Krag, Pere Ginès.
Machine learning outperforms existing non-invasive tests as screening tool for liver fibrosis in the general population
Journal of Hepatology. 73, 2020. Oral presentation to ILC2020. doi: https://doi.org/10.3390/jcm10050930
Graupera I, Thiele M, Serra-Burriel M, Caballeria L, Roulot D, Wong GL, Fabrellas N, Guha IN, Arslanow A, Expósito C, Hernández R, Aithal GP, Galle PR, Pera G, Wong VW, Lammert F, Ginès P, Castera L, Krag A; Investigators of the LiverScreen Consortium.
Low Accuracy of FIB-4 and NAFLD Fibrosis Scores for Screening for Liver Fibrosis in the Population
Clin Gastroenterol Hepatol. 2022 Nov;20(11):2567-2576.e6. DOI: : 10.1016/j.cgh.2021.12.034. Epub 2021 Dec 29.
Miquel Serra-Burriel, Adrià Juanola, Feliu Serra-Burriel, Maja Thiele, Isabel Graupera, Elisa Pose, Guillem Pera, Ivica Grgurevic, Llorenç Caballeria, Salvatore Piano, Laurens van Kleef, Mathias Reichert, Dominique Roulot, Juan M Pericàs, Jörn M Schattenberg, Emmanuel A Tsochatztis, Indra Neil Guha, Montserrat Garcia-Retortillo, Rosario Hernández, Jordi Hoyo, Matilde Fuentes, Carmen Expósito, Alba Martínez, Patricia Such, Anita Madir, Sönke Detlefsen, Marta Tonon, Andrea Martini, Ann T Ma, Judith Pich, Eva Bonfill, Marta Juan, Anna Soria, Marta Carol, Jordi Gratacós-Ginès, Rosa M Morillas, Pere Toran, J M Navarrete, Antoni Torrejón, Céline Fournier, Anne Llorca, Anita Arslanow, Harry J de Koning, Fernando Cucchietti, Michael Manns, Phillip N Newsome, Rubén Hernáez, Alina Allen, Paolo Angeli, Robert J de Knegt, Tom H Karlsen, Peter Galle, Vincent Wai-Sun Wong, Núria Fabrellas, Laurent Castera, Aleksander Krag, Frank Lammert, Patrick S Kamath, Pere Ginès; LiverScreen Consortium Investigators.
Development, validation, and prognostic evaluation of a risk score for long-term liver-related outcomes in the general population: a multicohort study.
Lancet. 2023 Sep 16;402(10406):988-996 doi: 10.1016/S0140-6736(23)01174-1. Epub 2023 Aug 9.
This is not eligible for open access because this option is not allowed in the Lancet, however it is of primary significance for the LiverScreen project.
Anette Søgaard Nielsen, Gro Askgaard and Maja Thiele.
Treatment of alcohol use disorder in patients with liver disease.
Current Opinion in Pharmacology 2022, 62:145–151 doi: 10.1016/j.coph.2021.11.012
Maria Kjaergaard, Katrine Prier Lindvig, Katrine Holtz Thorhauge, Peter Andersen, Johanne Kragh Hansen, Nanna Kastrup, Jane Møller Jensen, Camilla Dalby Hansen, Stine Johansen, Mads Israelsen, Nikolaj Torp, Morten Beck Trelle, Shan Shan, Sönke Detlefsen, Steen Antonsen, Jørgen Ellegaard Andersen, Isabel Graupera, Pere Ginés, Maja Thiele, Aleksander Krag.
Using the ELF test, FIB-4 and NAFLD fibrosis score to screen the population for liver disease.
Journal of Hepatology, 2023. vol. 79 j 277–286. doi: 10.1016/j.jhep.2023.04.002
Maria Kjaergaard; Katrine Prier Lindvig; Katrine Holtz Thorhauge; Stine Johansen; Johanne Kragh Hansen; Peter Andersen; Camilla Dalby Hansen; Helle Lindholm Schnefeld; Katrine Tholstrup Bech; Nikolaj Torp; Mads Israelsen; Sönke Detlefsen; Isabel Graupera; Pere Gines; Aleksander Krag; Maja Thiele.
Screening for Fibrosis Promotes Lifestyle Changes: A Prospective Cohort Study in 4796 Individuals.
Clin Gastroenterol Hepatol. 2024 May;22(5):1037-1047.e9. doi: 10.1016/j.cgh.2023.12.018.
Below are relevant publications in conference proceeding/workshop resulting from the project and acknowledging LiverScreen funding*.
Helle Lindholm Schnefeld, Katrine P. Lindvig, Anita Arslanow, Isabel Graupera, Maria Kjaergaard, Katrine H. Thorhauge, Johanne K. Hansen, Camilla D. Hansen, Stine Johansen, Mads Israelsen, Peter Andersen, Nikolaj Torp, Katrine Tholstrup Bech, Sönke Detlefsen, Pere Gines, Aleksander Krag, Maja Thiele. Health-related quality of life in an at-risk population. Poster presentation at ILC2023, Vienna, Austria.
Helle Lindholm Schnefeld, Katrine P. Lindvig, Anita Arslanow, Isabel Graupera, Maria Kjaergaard, Katrine H. Thorhauge, Johanne K. Hansen, Camilla D. Hansen, Stine Johansen, Mads Israelsen, Peter Andersen, Nikolaj Torp, Katrine Tholstrup Bech, Sönke Detlefsen, Nuria Fabrellas, Pere Gines, Aleksander Krag, Maja Thiele. Health-related quality of life in a population at-risk of NAFLD or ALD. Poster presentation at GARPS 2023, Bad Kreuznach, Germany.
Ida F Villesen, Isabel Graupera, Guillem Pera, Miquel Serra-Burriel, Anita Arslanow, Johanne K Hansen, Helle L Schnefeld, Camilla D Hansen, Mads Israelsen, Katrine P. Lindvig, Katrine T Bech, Peter Andersen, Robert J. de Knegt, Frank Lammert, Laurent Castera, Ivica Grgurevic, Salvatore Piano, Núria Fabrellas, Indra Neil Guha, Emmanouil A Tsochatzis, Jörn Schattenberg, Juan Manuel Pericas, Llorenç Caballeria, Aleksander Krag, Pere Gines and Maja Thiele on behalf of the LiverScreen consortium. Short-term variation in transient elastography measurements when used as a population screening tool. Poster presentation at AASLD2023, Boston, USA.
Mary E. Rinella1, Michael R. Charlton2, Miquel Serra Burriel3, Pere Ginès4, Yestle Kim2, Joe Medicis2,Suneil Hosmane2, Jonathan J. Woolley5, Christina M. Parrinello6, Tom Oconnell5. Use of the LiverRisk Score for prediction of moderate to advanced liver fibrosis in United States adults. Abstract presentation at EASL 2025.
Jesse Pustjens, Katrine Tholstrup Bech. Liver stiffness dynamics in the general population. Oral presentation at The Liver Meeting, AASLD 2025, Washington DC.
Jesse Pustjens, Katrine Tholstrup Bech. Blood based NIT’s to predict LSM dynamics. Poster presentation at The Liver Meeting, AASLD 2025, Washington DC.
Jesse Pustjens, Katrine Tholstrup Bech. LSM progression and regression in individuals with T2DM. Poster presentation at The Liver Meeting, AASLD 2025, Washington DC.
Isabel Graupera, Maja Thiele, Ann T Ma, Miquel Serra-Burriel, Judit Pich, Núria Fabrellas, Llorenç Caballeria, Robert J de Knegt, Ivica Grgurevic, Mathias Reichert, Dominique Roulot, Jörn M Schattenberg, Juan M Pericas, Paolo Angeli, Emmanuel A Tsochatzis, Indra Neil Guha, Montserrat Garcia-Retortillo, Rosa M Morillas, Rosario Hernández, Jordi Hoyo, Matilde Fuentes, Anita Madir, Adrià Juanola, Anna Soria, Marta Juan, Marta Carol, Alba Diaz, Sönke Detlefsen, Pere Toran, Céline Fournier, Anne Llorca, Phillip N Newsome, Michael Manns, Harry J de Koning, Feliu Serra-Burriel, Fernando Cucchietti, Anita Arslanow, Marko Korenjak, Laurens van Kleef, Josep Lluis Falcó, Patrick S Kamath, Tom H Karlsen, Laurent Castera, Frank Lammert, Aleksander Krag, Pere Ginès for the LiverScreen Consortium investigators. LiverScreen Project: study protocol for screening for liver fibrosis in the general population in European countries. Poster presentation at GARPS 2022, Bad Kreuznach, Germany.
Miquel Serra-Burriel, Isabel Graupera , Maja Thiele , Llorenç Caballeria, Dominique Roulot, Grace Lai-Hung Wong, Núria Fabrellas , Neil Guha, Anita Arslanow Carmen Expósito , Rosario Hernández, Guruprasad Aithal , Peter Galle, Vincent Wai-Sun Wong, Frank Lammert, Castera Laurent, Aleksander Krag, Pere Ginès. Machine learning outperforms existing non-invasive tests as screening tool for liver fibrosis in the general population. Journal of Hepatology, 73, 2020. Oral presentation to ILC2020. DOI: https://doi.org/10.1016/S0168-8278(20)30678-4
Isabel Graupera, Miquel Serra-Burriel, Maja Thiele, Llorenç Caballeria, Dominique Roulot, Grace Lai-Hung Wong, Núria Fabrellas , Neil Guha, Anita Arslanow, Carmen Expósito, Rosario Hernández, Guruprasad Aithal, Peter Galle, Vincent Wai-Sun Wong, Frank Lammert, Pere Ginès , Castera Laurent, Aleksander Krag. Value of FIB-4 and NAFLD fibrosis scores for screening of liver fibrosis in the general population. Journal of Hepatology, 73, 2020. Poster presentation to ILC2020. DOI: https://doi.org/10.1016/S0168-8278(20)31314-3
*These are not in open access because this is an abstract issue of the EASL international congress.
Miquel Serra-Burriel, Isabel Graupera, Pere Torán, Maja Thiele, Dominique Roulot, Vincent Wai-Sun Wong, Indra Neil Guha, Núria Fabrellas, Anita Arslanow, Carmen Expósito, Rosario Hernández, Grace Lai-Hung Wong, David Harman, Sarwa Darwish Murad, Aleksander Krag, Guillem Pera, Paolo Angeli, Peter Galle, Guruprasad P Aithal, Llorenç Caballeria, Laurent Castera, Pere Ginès, Frank Lammert, investigators of the LiverScreen Consortium.
Transient elastography for screening of liver fibrosis: Cost-effectiveness analysis from six prospective cohorts in Europe and Asia
J Hepatol. 2019 Dec;71(6):1141-1151. doi: 10.1016/j.jhep.2019.08.019. Epub 2019 Aug 27.PMID: 31470067
Ginès P, Graupera I, Lammert F, Angeli P, Caballeria L, Krag A, Guha IN, Murad SD, Castera L.
Screening for liver fibrosis in the general population: a call for action
Lancet Gastroenterol Hepatol. 2016 Nov;1(3):256-260. doi: 10.1016/S2468-1253(16)30081-4. Epub 2016 Oct 12
Isabel Graupera, Frank Lammert.
Screening is caring: Community-based non-invasive diagnosis and treatment strategies for hepatitis C to reduce liver disease burden
Journal of Hepatology. 2018 vol. 69 j 562–563. Editorial. doi: 10.1016/j.jhep.2018.06.001